My son was always awake in the middle of the night..if she's crying and the norms dont work (like nursing and rocking) she probably has reflux or an allergy. Try some Mylicon drops, or Gripe Water (gentle naturals). Ease up on the diary products and you can also try getting a wedge for under the mattress so she's not laying flat. If none of those don't work you can try Zantac.