Has anyone heard about/used Deplin? http://www.deplin.com/ Its folic acid in its most readily absorbable form and is capable of passing the blood-brain barrier. The technical name for it is L-methylfolate (MTHF) and its available only by prescription and is classified as medical food (??). It is being marketed as an augmentation to antidepressants to increase effectiveness of the medication. My sons therapist has been using it stand-alone to treat depression and has seen improvement in 15 of 15 patients. I wonder, since its used to augment ADs, if it would be activating for some. I found this http://www.dr-bob.org/babble/20071225/msgs/803728.html Anyway, just passing the information along in case its helpful for anyone.