buddy
New Member
Q was to have a cavity filled and it hit me just when I woke that I never told the dentist about his CYP450 2d6 and 2c19 poor metabolizer issues....
So I called the dentist and he said we had to cancel and he had to do some research because he doesn' want him in pain...it could be nothing or it may mean we need another plan...
BUT, I have to research this of course, LOL
and I remember some here wondering if they had CYP enzyme issues because they or their difficult child had weird medication. issues.
Almost 25% of all drugs on the market today are broken down by a specific
enzyme within the Cytochrome P450 class of enzymes known as CYP 2D6. This
is well known by chemical scientists. What is less known, and what big
pharma has tried to keep under wraps is that not everyone has this enzyme,
and for those that do - there may be subtle variations or "defects" in their
genetic makeup so that not everyone produces the same amount of this enzyme.
This science is so well understood that the population has been divided
into four main categories, and they are:
1. Ultra extensive metabolizers
2. Extensive metabolizers
3. Intermediate metabolizer
4. Poor metabolizer
Now let me provide you with a couple of examples to help you better
understand why this information is so important.
Let's say that someone is an ultra extensive metabolizer of Novocaine. This
means that this person produces an "excess" amount of the enzyme that breaks
down Novocaine and helps to clear this chemical from the person's body. So,
when this person goes to the dentist to have some work done, the dentist
administers the standard dose of Novocaine, and believing that his patient
is now numb, begins to work. The patient screams out in pain because the
standard dose of Novocaine had no effect. The patient's enzymes broke down
the Novocaine quickly, before the drug could produce its intended effect.
Now, lets say that Prozac is prescribed for a poor metabolizer. This
patient has a genetic variant which results in very little production of CYP
2D6. Not only that, but the patient has also been taking another drug which
needs CYP 2D6 enzyme for break down and clearance. Because the enzyme which
breaks down Prozac is deficient, levels of the drug soon build to toxic
levels.
So I called the dentist and he said we had to cancel and he had to do some research because he doesn' want him in pain...it could be nothing or it may mean we need another plan...
BUT, I have to research this of course, LOL
and I remember some here wondering if they had CYP enzyme issues because they or their difficult child had weird medication. issues.
Almost 25% of all drugs on the market today are broken down by a specific
enzyme within the Cytochrome P450 class of enzymes known as CYP 2D6. This
is well known by chemical scientists. What is less known, and what big
pharma has tried to keep under wraps is that not everyone has this enzyme,
and for those that do - there may be subtle variations or "defects" in their
genetic makeup so that not everyone produces the same amount of this enzyme.
This science is so well understood that the population has been divided
into four main categories, and they are:
1. Ultra extensive metabolizers
2. Extensive metabolizers
3. Intermediate metabolizer
4. Poor metabolizer
Now let me provide you with a couple of examples to help you better
understand why this information is so important.
Let's say that someone is an ultra extensive metabolizer of Novocaine. This
means that this person produces an "excess" amount of the enzyme that breaks
down Novocaine and helps to clear this chemical from the person's body. So,
when this person goes to the dentist to have some work done, the dentist
administers the standard dose of Novocaine, and believing that his patient
is now numb, begins to work. The patient screams out in pain because the
standard dose of Novocaine had no effect. The patient's enzymes broke down
the Novocaine quickly, before the drug could produce its intended effect.
Now, lets say that Prozac is prescribed for a poor metabolizer. This
patient has a genetic variant which results in very little production of CYP
2D6. Not only that, but the patient has also been taking another drug which
needs CYP 2D6 enzyme for break down and clearance. Because the enzyme which
breaks down Prozac is deficient, levels of the drug soon build to toxic
levels.