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<blockquote data-quote="Sara PA" data-source="post: 153162" data-attributes="member: 1498"><p>Eighty mgs of Vyvanse is 10 mg more than the maximum recommended dose of 70 mg/day. The recommended dose is 30 mg/day. Did his violence and uncontrollable outbursts start or get worse after he started taking the Vyvanse, especially at that very high dose? These are the psychiatric adverse reactions to Vyvanse:</p><p></p><p><em><strong>5.2 Psychiatric Adverse Events</strong></em></p><p><em><strong>Pre-existing Psychosis</strong></em></p><p><em>Administration of stimulants may exacerbate symptoms of behavior disturbance and thought disorder in patients with a pre-existing psychotic disorder.</em></p><p><em><strong>Bipolar Illness</strong></em></p><p><em>Particular care should be taken in using stimulants to treat ADHD in patients with comorbid bipolar disorder because of concern for possible induction of a mixed/manic episode in such patients. Prior to initiating treatment with a stimulant, patients with comorbid depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder. Such screening should include a detailed psychiatric history, including a family history of suicide, bipolar disorder and depression.</em></p><p><em><strong>Emergence of New Psychotic or Manic Symptoms</strong></em></p><p><em>Treatment-emergent psychotic or manic symptoms, e.g. hallucinations, delusional thinking, or mania in children and adolescents without a prior history of psychotic illness or mania can be caused by stimulants at usual doses. If such symptoms occur consideration should be given to a possible causal role of the stimulant, and discontinuation of treatment may be appropriate. In a pooled analysis of multiple shortterm, placebo-controlled studies, such symptoms occurred in about 0.1% (4 patients with events out of 3482 exposed to methylphenidate or amphetamine for several weeks at usual doses) or stimulant-treated patients compared to 0 in placebo-treated patients.</em></p><p><em><strong>Aggression</strong></em></p><p><em>Aggressive behavior or hostility is often observed in children and adolescents with ADHD, and has been reported in clinical trials and the post marketing experience of some medications indicated for the treatment of ADHD. Although there is no systematic evidence that stimulants cause aggressive behavior or hostility, patients beginning treatment of ADHD should be monitored for the appearance of, or worsening of, aggressive behavior or hostility.</em></p><p></p><p>It is entirely possible that a good part of the problem is the Vyvanse.</p><p></p><p>by the way, Strattera is an antidepressant. It sounds as if it induced mania almost immediately. That is a fairly common psychiatric adverse reaction to antidepressants. Keep that in mind if anyone suggests an antidepressant again.</p></blockquote><p></p>
[QUOTE="Sara PA, post: 153162, member: 1498"] Eighty mgs of Vyvanse is 10 mg more than the maximum recommended dose of 70 mg/day. The recommended dose is 30 mg/day. Did his violence and uncontrollable outbursts start or get worse after he started taking the Vyvanse, especially at that very high dose? These are the psychiatric adverse reactions to Vyvanse: [I][B]5.2 Psychiatric Adverse Events[/B] [B]Pre-existing Psychosis[/B] Administration of stimulants may exacerbate symptoms of behavior disturbance and thought disorder in patients with a pre-existing psychotic disorder. [B]Bipolar Illness[/B] Particular care should be taken in using stimulants to treat ADHD in patients with comorbid bipolar disorder because of concern for possible induction of a mixed/manic episode in such patients. Prior to initiating treatment with a stimulant, patients with comorbid depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder. Such screening should include a detailed psychiatric history, including a family history of suicide, bipolar disorder and depression. [B]Emergence of New Psychotic or Manic Symptoms[/B] Treatment-emergent psychotic or manic symptoms, e.g. hallucinations, delusional thinking, or mania in children and adolescents without a prior history of psychotic illness or mania can be caused by stimulants at usual doses. If such symptoms occur consideration should be given to a possible causal role of the stimulant, and discontinuation of treatment may be appropriate. In a pooled analysis of multiple shortterm, placebo-controlled studies, such symptoms occurred in about 0.1% (4 patients with events out of 3482 exposed to methylphenidate or amphetamine for several weeks at usual doses) or stimulant-treated patients compared to 0 in placebo-treated patients. [B]Aggression[/B] Aggressive behavior or hostility is often observed in children and adolescents with ADHD, and has been reported in clinical trials and the post marketing experience of some medications indicated for the treatment of ADHD. Although there is no systematic evidence that stimulants cause aggressive behavior or hostility, patients beginning treatment of ADHD should be monitored for the appearance of, or worsening of, aggressive behavior or hostility.[/I] It is entirely possible that a good part of the problem is the Vyvanse. by the way, Strattera is an antidepressant. It sounds as if it induced mania almost immediately. That is a fairly common psychiatric adverse reaction to antidepressants. Keep that in mind if anyone suggests an antidepressant again. [/QUOTE]
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