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The Watercooler
husband's Seizure Medication Quandary
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<blockquote data-quote="rlsnights" data-source="post: 306008" data-attributes="member: 7948"><p>So, this is the only study listed at Clinical Trials.gov for partial seizures that is from UCB.</p><p></p><p><a href="http://clinicaltrials.gov/ct2/show/NCT00955357?recr=Open&cond=&#37;22Epilepsies,+Partial%22&rank=21" target="_blank">http://clinicaltrials.gov/ct2/show/NCT00955357?recr=Open&cond=&#37;22Epilepsies,+Partial"&rank=21</a></p><p></p><p>The study description doesn't match your husband's description - it's open label, single group with the medication (Vimpat) used as an add on medication to first AED. Irvine, CA is listed as one of the locations.</p><p></p><p>The drug maker is UCB. I couldn't find any other study by UCB that was placebo, double blind randomized.</p><p></p><p>It does appear that the medication is not available after the trial through the maker because the description includes a 3 week taper period. However, this drug is already on the market so ??? It's a schedule V controlled substance but it is available.</p><p></p><p>Nothing in the posted info about an extension phase although I suppose that might be coming down the pike depending on the results.</p><p></p><p>Are you familiar with the Crazy medications website? If not here's a link</p><p></p><p><a href="http://www.crazymeds.us/" target="_blank">http://www.crazymeds.us/</a></p><p></p><p>You might want to cruise through the info about seizure medications. Says max dose of Trileptal is 2400 in 300 mg increments. Also says it's not as powerful as Tegretol. So there's not a lot of room to go up on the Trileptal from where he's at now. Has he tried playing with dosing - I assume he's doing split doses. Does it makes sense to do 3 times a day or to do more in the morning vs. evening? It has a pretty linear and short half life in two passes with the longest being 9 hours.</p><p></p><p>I understand the docs concern about SJS but if Lamictal worked really well and he didn't actually develop SJS I might be tempted to ask about adding a small dose of Lamictal to the Trileptal. Just a thought.</p><p></p><p>Hope you find some answers soon.</p></blockquote><p></p>
[QUOTE="rlsnights, post: 306008, member: 7948"] So, this is the only study listed at Clinical Trials.gov for partial seizures that is from UCB. [url]http://clinicaltrials.gov/ct2/show/NCT00955357?recr=Open&cond=%22Epilepsies,+Partial%22&rank=21[/url] The study description doesn't match your husband's description - it's open label, single group with the medication (Vimpat) used as an add on medication to first AED. Irvine, CA is listed as one of the locations. The drug maker is UCB. I couldn't find any other study by UCB that was placebo, double blind randomized. It does appear that the medication is not available after the trial through the maker because the description includes a 3 week taper period. However, this drug is already on the market so ??? It's a schedule V controlled substance but it is available. Nothing in the posted info about an extension phase although I suppose that might be coming down the pike depending on the results. Are you familiar with the Crazy medications website? If not here's a link [url]http://www.crazymeds.us/[/url] You might want to cruise through the info about seizure medications. Says max dose of Trileptal is 2400 in 300 mg increments. Also says it's not as powerful as Tegretol. So there's not a lot of room to go up on the Trileptal from where he's at now. Has he tried playing with dosing - I assume he's doing split doses. Does it makes sense to do 3 times a day or to do more in the morning vs. evening? It has a pretty linear and short half life in two passes with the longest being 9 hours. I understand the docs concern about SJS but if Lamictal worked really well and he didn't actually develop SJS I might be tempted to ask about adding a small dose of Lamictal to the Trileptal. Just a thought. Hope you find some answers soon. [/QUOTE]
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