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The Watercooler
husband's Seizure Medication Quandary
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<blockquote data-quote="rlsnights" data-source="post: 306060" data-attributes="member: 7948"><p>I believe that all double blind studies in patients (as opposed to healthy individuals) have an escape clause for patients that experience a worsening of their condition while in the study. Usually there's an intermediate step where you switch to open label and increase or modify the dosing conditions in some way and then quitting if that still doesn't work. You can thank the AIDS movement activists for that shift in the status quo.</p><p></p><p>So, yes, it would not be great if he got placebo but generally such a study is focusing on decreasing frequency/degree of sx and doesn't get approved by Human Subjects if there's no option for patients who get worse to be treated.</p><p></p><p>Plus you can ALWAYS quit the study at any time.</p></blockquote><p></p>
[QUOTE="rlsnights, post: 306060, member: 7948"] I believe that all double blind studies in patients (as opposed to healthy individuals) have an escape clause for patients that experience a worsening of their condition while in the study. Usually there's an intermediate step where you switch to open label and increase or modify the dosing conditions in some way and then quitting if that still doesn't work. You can thank the AIDS movement activists for that shift in the status quo. So, yes, it would not be great if he got placebo but generally such a study is focusing on decreasing frequency/degree of sx and doesn't get approved by Human Subjects if there's no option for patients who get worse to be treated. Plus you can ALWAYS quit the study at any time. [/QUOTE]
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