Has anyone ever had a difficult child experience a drastic increase irritability and depressive symptoms while taking Risperdal? difficult child began Risperdal in late January to help with Autism Spectrum Disorders (ASD)-related anxiety. He started on the initial dose of 0.25mg at bedtime. They increased his dose to 1mg at bedtime a month ago. What a nightmare. He'd wake up in the middle of the night in a big panic and then have a lot of trouble getting back to sleep. After a week of this, the psychiatrist cut the bedtime dose to 0.5mg at bedtime and 0.25mg in the morning and 0.25 after school. Since the increase especially, his irritability has seemed to increase drastically, especially at school. He blows at the drop of a hat and is inconsolable. When he is at home, he seems very depressed with an occasional out-of-nowhere blowup. He apologizes constantly for getting into trouble at school and for ruining my life (his words not mine) and he doesn't know why he does what he does and on and on. The only medication change has been the addition of the Risperdal. Could that be causing this? He has always been medication sensitive but these "behaviors" are not listed as a side effect of Risperdal in any of the info I have read about it. Anyone have any insight/advice?