difficult child 2 has Obsessive Compulsive Disorder (OCD) and migraines. To try to make a long story short, her migraines were controlled at one point by Elavil. Then we tried to help her with her Obsessive Compulsive Disorder (OCD) with SSRI's. She tried most of the SSRI's and Anafranil and had enough side effects with each one that we gave up on that for a while. Some of the SSRI's required that she give up the Elavil. We have never been able to get her migraines back under control since then. We recently tried the Elavil again and it didn't seem to be helping but now that she is not taking it, she is complaining more about her head. Her head always hurts enough that she is unable to go to school or play with friends, etc. We took her off from it again because we were thinking it wasn't helping much and we wanted to try to work on the Obsessive Compulsive Disorder (OCD) again. We are starting with a small dose of Zoloft. She was taken off from the Zoloft the last time because it affected her appetite and she lost a little bit of weight. This was the first one we tried and we thought there would be success with another one. We are trying the liquid form with a small dose. Her psychiatrist is opposed to using Elavil with Zoloft. He suggests that we ask her doctor about Topomax for the migraines. I think her neurologist is ok about using Elavil and Zoloft together but since it wasn't all that effective, it wouldn't hurt to try something different. The last time we saw him, about a year ago, he suggested she drink more water and do yoga. The only reason I am going back is that I think he will say she can do the Elavil and Zoloft together or prescribe Topomax. But I am not even sure that is what we should do. difficult child 2 has another chronic health condition and I was told by that doctor's office that Topomax could cause weight loss, too. Both her headaches and her Obsessive Compulsive Disorder (OCD) are pretty disabling right now. Her headaches are keeping her home from school so her Obsessive Compulsive Disorder (OCD) is less of a social issue now, but if she were living a normal life, I think her Obsessive Compulsive Disorder (OCD) would be a big problem, too. Does anyone have any advice about this whole situation? Unfortunately, I think it is up to husband and me (mostly me) to figure out the right approach.