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<blockquote data-quote="smallworld" data-source="post: 397160" data-attributes="member: 2423"><p>Hi Marg, because of potentially lethal dietary and drug interactions, MOA inhibitors have historically been reserved as a last line of treatment, used only when other classes of antidepressant drugs (for example <a href="http://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor" target="_blank">http://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor</a>SSRIs and tricyclics) have failed. However, Moclobemide is a newer MAO that doesn't have the same dietary restrictions so it is being prescribed a bit more frequently. But you won't ever see it used in the pediatric population so folks here won't be all that familiar with it. Both insomnia and increased anxiety are listed as side effects so it's quite possible your daughter in law is experiencing those symptoms from the Moclobemide. I'm not certain why the doctor feels an increase would make the side effects better (and not worse).</p><p></p><p>Just so you know, 26 years ago, my mother took an MAO (not sure which one) for depression, became delusional and took an overdose to end her life. Fortunately, my father found her before it was too late. So it can and does happen. At the time her psychiatrist didn't listen to my parents either (and my father's a doctor). So I would urge your son and daughter in law to keep pushing until a doctor believes them that the medication is causing side effects that are harmful to her mental health. She should be switched to a medication that is better for her overall mental health.</p><p></p><p>I'll be holding a positive thought for your son and daughter in law.</p></blockquote><p></p>
[QUOTE="smallworld, post: 397160, member: 2423"] Hi Marg, because of potentially lethal dietary and drug interactions, MOA inhibitors have historically been reserved as a last line of treatment, used only when other classes of antidepressant drugs (for example [URL="http://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor"][/URL]SSRIs and tricyclics) have failed. However, Moclobemide is a newer MAO that doesn't have the same dietary restrictions so it is being prescribed a bit more frequently. But you won't ever see it used in the pediatric population so folks here won't be all that familiar with it. Both insomnia and increased anxiety are listed as side effects so it's quite possible your daughter in law is experiencing those symptoms from the Moclobemide. I'm not certain why the doctor feels an increase would make the side effects better (and not worse). Just so you know, 26 years ago, my mother took an MAO (not sure which one) for depression, became delusional and took an overdose to end her life. Fortunately, my father found her before it was too late. So it can and does happen. At the time her psychiatrist didn't listen to my parents either (and my father's a doctor). So I would urge your son and daughter in law to keep pushing until a doctor believes them that the medication is causing side effects that are harmful to her mental health. She should be switched to a medication that is better for her overall mental health. I'll be holding a positive thought for your son and daughter in law. [/QUOTE]
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