Anyone know the difference between skelaxin and flexeril? My doctor prescribed skelaxin but my insurance company requires prior-authorization (on EVERYTHING) and the pharmacist said they will probably make me take flexeril. I'm having horrible muscle cramps all over my body. Literally. Around my ribs, back, right hip, buttock, thigh and calf (stretched in my sleep yesterday and ended up with a charlie horse in my right calf that had my foot pulled into a ballet point) and even in my throat. That one's a bit disconcerting. The skelaxin is working (doctor gave me samples). Flexeril has a generic while skelaxin doesn't which is what the insurance has issues with. I'm wondering if one is better than the other or what the difference is - if anyone knows. I already asked the pharmacist and they are both ok to take with my other medications.