Has anyone noticed that since their child has started taking medications that their personality changes when they aren't on them? Every time that difficult child has taken medications we have noticed in the morning before he takes them that he is much more agressive and angrier than before we started them. This morning for example he lost it, I mean the anger was scary, just because the dog had dripped water on the floor from her water bowl and he stepped in it. Honestly if he had the opportunity to have killed someone he probably could have. Once the medications kicked in, he was fine. But the thing is is that during the summer when he's not on anything, we don't see this. I run a daycare and if one of them does something wrong there are times where he'll say "I hate them" but the anger behind it just doesn't seem appropriate. This is not my usual kid, at least not for quite a few years. When he was 2 1/2, he was violent and destructive. He was diagnosed then with ODD and we were told he had little to no conscience. We have gotten it under control and he is now very thoughtful but I have found since he has started with the concerta/clonidine his personality when he is not on the medications (and more so in the morning) is scary. My husband is convinced that he has a split personality or something. He goes this violent/angry way and then a couple minutes later, he's fine. Could it be the medications causing this? Anyone else have anything similar?