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Seroquel XR and Depakote questions
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<blockquote data-quote="smallworld" data-source="post: 120981" data-attributes="member: 2423"><p>The first medication my son took after his manic reaction to Zoloft (which set us down the mood disorder path) was Depakote. He went all the way up to 1000 mg and it stopped the mania dead in its tracks in 6 weeks. But then he plunged into a deep depression. We then lowered the Depakote to 500 mg and added in Lamictal for depression. In time, when his depression didn't life, we Difficult Child'd Depakte and went up to 400 mg Lamictal (he's now maxed out on that medication). </p><p> </p><p>My daughter (easy child/difficult child 2) had a similar experience with Depakote. She went up to 1125 mg (blood level 125). As the dose got higher, she became more irritable, spacey and depressed. We eventually Difficult Child'd Depakote and put her on Lamictal as well.</p><p> </p><p>According to The Bipolar Child, some kids do well on Depakote blood levels of 80 to 90, but others require between 100 and 125. It takes 6 to 8 weeks at a therapeutic dose for full efficacy. </p><p> </p><p>It's hard to know exactly what's going on with Bugsy, but he is not in the therapeutic window for Depakote. Sometimes you have to give a medication a fair chance for a while so you can know with certainty what's going on before Difficult Child'ing the medication too quickly.</p><p> </p><p>My son started Seroquel in late December for mania, anxiety, depression and sleep. He is now up to 800 mg and takes his entire dose at bedtime. For the first time in two years of medication trials, his depression is lifting and he is becoming less oppositional. I'm finally beginning to see the son I knew before Zoloft changed his life.</p><p> </p><p>A week ago, I asked his psychiatrist about Seroquel XR, and he said, "I've had no problems with regular Seroquel so I see no reason to switch." So we're going along with "if it ain't broke, don't fix it." A couple of moms on a BiPolar (BP) parent listserv I co-moderate had their children trial Seroquel XR and ended up switching back to regular because they didn't feel the XR version worked as well. </p><p> </p><p>I'm sorry Bugsy continues to struggle. I hope you hit on good medication combo soon.</p></blockquote><p></p>
[QUOTE="smallworld, post: 120981, member: 2423"] The first medication my son took after his manic reaction to Zoloft (which set us down the mood disorder path) was Depakote. He went all the way up to 1000 mg and it stopped the mania dead in its tracks in 6 weeks. But then he plunged into a deep depression. We then lowered the Depakote to 500 mg and added in Lamictal for depression. In time, when his depression didn't life, we Difficult Child'd Depakte and went up to 400 mg Lamictal (he's now maxed out on that medication). My daughter (easy child/difficult child 2) had a similar experience with Depakote. She went up to 1125 mg (blood level 125). As the dose got higher, she became more irritable, spacey and depressed. We eventually Difficult Child'd Depakote and put her on Lamictal as well. According to The Bipolar Child, some kids do well on Depakote blood levels of 80 to 90, but others require between 100 and 125. It takes 6 to 8 weeks at a therapeutic dose for full efficacy. It's hard to know exactly what's going on with Bugsy, but he is not in the therapeutic window for Depakote. Sometimes you have to give a medication a fair chance for a while so you can know with certainty what's going on before Difficult Child'ing the medication too quickly. My son started Seroquel in late December for mania, anxiety, depression and sleep. He is now up to 800 mg and takes his entire dose at bedtime. For the first time in two years of medication trials, his depression is lifting and he is becoming less oppositional. I'm finally beginning to see the son I knew before Zoloft changed his life. A week ago, I asked his psychiatrist about Seroquel XR, and he said, "I've had no problems with regular Seroquel so I see no reason to switch." So we're going along with "if it ain't broke, don't fix it." A couple of moms on a BiPolar (BP) parent listserv I co-moderate had their children trial Seroquel XR and ended up switching back to regular because they didn't feel the XR version worked as well. I'm sorry Bugsy continues to struggle. I hope you hit on good medication combo soon. [/QUOTE]
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