So difficult child is being cross tapered from Abilify to Seroquel. He is currently at 7.5mg Abilify (was at 15mg twice a day) and 200mg Seroquel. I spoke to him last night, and his irritability is way up. He says he is tired (he always says that even if he is crazy active, I think his body gets tired but his mind won't let him slow down.). for those who know anything about Seroquel (I only know what I have read) at what dose did you see if it was going to work or not? How long does it have to be in the system before you can expect to see something?