I remembered today that i had emailed the school a week or so ago and told them about difficult child's medication changes and what signs to watch for in case the mood cycling might be starting. I told them that the medication changes were due to difficult child having serious signs of depression and that if this was turning into mania or more serious depression issues that the first signs would include disruption in class, not complying with rules (whether or not this is all deliberate or just inability to do certain things like sit still and pay attention, who knows), inability to focus on what he should be doing, and not complying when re-directed. If he is fussed at over these things, he will start acting rebellious. Whereas this appears to be complete defiance and generally results in anger of the authority figure, so far, these "indicators" have always preceded erratic behavior in difficult child. Then, I realized that this is exactly what I'm seeing in difficult child the past few days at home. I have put the medications back where they were (I think it was too much too fast, with the albuterol and all) Hopefully, I have done this in time. But, I was wondering if this is seen by anyone else in their difficult child who has mood cycling? Inevitably, while I'm going thru it with my son, I always feeling like he is deliberatley being defiant and disrespectful. Then, after the manic bout or the period of "completely losing it", I look back and see this stage as the precursor. Is this common? Do you think it's really a part of mood cycling or is it just a stage of difficult child being defiant and not caring and he gives up and gives into too much that leads to mania or irrational behavior?