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Why do antidepressant work? Incredibly fascinating lecture in You Tube
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<blockquote data-quote="SuZir" data-source="post: 595464" data-attributes="member: 14557"><p>Nothing quite as good in text as that lecture, but here is one magazine article from the topic: <a href="http://www.scientificamerican.com/article.cfm?id=prozac-extinguishes-anxiety-rejuvenating-brain" target="_blank">http://www.scientificamerican.com/article.cfm?id=prozac-extinguishes-anxiety-rejuvenating-brain</a></p><p>here is one blog: <a href="http://scienceblogs.com/cortex/2010/04/22/prozac-and-plasticity/" target="_blank">http://scienceblogs.com/cortex/2010/04/22/prozac-and-plasticity/</a></p><p>And here are to research paper abstracts (you need an access to Medline to read whole papers, but abstracts do give an idea): <a href="http://www.ncbi.nlm.nih.gov/pubmed/22194582" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/22194582</a></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/20875703" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/20875703</a></p><p></p><p>In the original Italian research they were able to heal adult rat's 'lazy eye' with favouring the bad eye as well as they were usually able to do with baby rats and now they have a project to find out if same thing could be done with people. As you probably know 'lazy eyes' tend to be treatable by covering the good eye and favouring bad eye on small kids but if for some reason that is not done when kid is young, damage is permanent. It would be really cool if something as simple as SSRI and similar training as with kids could also help those whose 'lazy eyes' have not been treated properly as kids.</p><p></p><p>Other thing I found very interesting in the lecture was, that with mice the similar effect Prozac (that was a SSRI they used) gave with neural plasticity could be also achieved by taking mice from boring cages and putting them to stimulating cages. However mice that has always lived in stimulating cage didn't have that plasticity advantage because it wasn't new to them. And that could also explain why exercise seems to be a good 'medicine' to depression in humans. Starting SSRIs or exercising or more stimulating way of life could give us a window of recovery by giving us a possibility to revamp our neural connections same way child's neural connections are developed.</p><p></p><p>That of course made me think that cotton filled box in the attic... <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite2" alt=";)" title="Wink ;)" loading="lazy" data-shortname=";)" /> Maybe it wouldn't had been such a bad idea after all. Would had been easy to 'move difficult child to more stimulating cage' now. <img src="/community/styles/default/xenforo/smilies/Graemlins/rofl.gif" class="smilie" loading="lazy" alt=":rofl:" title="rofl :rofl:" data-shortname=":rofl:" /></p></blockquote><p></p>
[QUOTE="SuZir, post: 595464, member: 14557"] Nothing quite as good in text as that lecture, but here is one magazine article from the topic: [URL]http://www.scientificamerican.com/article.cfm?id=prozac-extinguishes-anxiety-rejuvenating-brain[/URL] here is one blog: [URL]http://scienceblogs.com/cortex/2010/04/22/prozac-and-plasticity/[/URL] And here are to research paper abstracts (you need an access to Medline to read whole papers, but abstracts do give an idea): [URL]http://www.ncbi.nlm.nih.gov/pubmed/22194582[/URL] [URL]http://www.ncbi.nlm.nih.gov/pubmed/20875703[/URL] In the original Italian research they were able to heal adult rat's 'lazy eye' with favouring the bad eye as well as they were usually able to do with baby rats and now they have a project to find out if same thing could be done with people. As you probably know 'lazy eyes' tend to be treatable by covering the good eye and favouring bad eye on small kids but if for some reason that is not done when kid is young, damage is permanent. It would be really cool if something as simple as SSRI and similar training as with kids could also help those whose 'lazy eyes' have not been treated properly as kids. Other thing I found very interesting in the lecture was, that with mice the similar effect Prozac (that was a SSRI they used) gave with neural plasticity could be also achieved by taking mice from boring cages and putting them to stimulating cages. However mice that has always lived in stimulating cage didn't have that plasticity advantage because it wasn't new to them. And that could also explain why exercise seems to be a good 'medicine' to depression in humans. Starting SSRIs or exercising or more stimulating way of life could give us a window of recovery by giving us a possibility to revamp our neural connections same way child's neural connections are developed. That of course made me think that cotton filled box in the attic... :winking: Maybe it wouldn't had been such a bad idea after all. Would had been easy to 'move difficult child to more stimulating cage' now. :rofl: [/QUOTE]
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Why do antidepressant work? Incredibly fascinating lecture in You Tube
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