I gained 10 lbs. 2 yrs ago when I had breast cancer. (Long story short, everyone said, Oh, no, how can we help? I said, Send chocolate. They did. I ate it. ) I have been exercising and am back on my normal routine. Still can't shake the extra lbs. It occurred to me that the Effexor I've been taking could be making wt loss even more difficult. I thought I could go off of it Effexor (in fact, went back down to 37.5 mg while difficult child was at camp. Yaay!) but now he's back and I need it again. It's only 10 lbs, but I'm short (5' 3-1/2" and shrinking) and I hate my loss of lower abs and my flabby inner thighs. In 2 yrs, I've gone from a size 2, to a 4, and now, almost a 6. I'm getting scared. I have increased my water intake, have given up most of my desserts while eating out (if someone else orders, I take a bite), never drink soda pop or beer, never put sugar in my decaf tea, never put butter on potatoes, etc., eat only skinless chicken and turkey, (we even make turkey burgers at home). I walk 3-4 miles 5X a wk. I am hypoglycemic, so have to eat something small every 3 hrs or so. I've narrowed it down to perimenopause, Effexor, and needing more exercise. Maybe that's all it is ... Both my parents gained wt at this age, but nothing awful, just middle-age spread. They both lost wt again when they got into their 70s. Help! Any experiences with-that medication? Should I be exercising harder? I don't have my physical for quite some time yet.