Just as I thought I was getting better, I had an extremely violent case of *%#* at a bookstore yesterday and did not make it to the bathroom in time. Thank d*G I was wearing thick jeans. I spent 1/2 hr cleaning up (not easy when you're in a stall, with-no WetWipes) and disposing of clothing. THAT's IT!!! It's been going on since before Thanksgiving and I've had it. (There was a JC Penney next door so I ran in and bought brand new underwear. A beggar had come up to my car and asked for money and all I could think of was, well, it could be worse--I could be poor, homeless, AND have a colon issue! And I'm lucky to have new pink undies. (*Hey, when you're embarrassed and stressed out, make the best of it. ) I can only go for 24 hr with-o an antidiarrheal, I'm eating probiotics and enzymes by the boatload, I've given up chocolate (Aaaaaaaaaaaaaaaaaaaaaarrrggghhh!) and cheese (I'd given up milk yrs ago), and the medications the GP gave me made me way too sleepy. I've had IBS since I was a kid, and started taking probiotics and enzymes about 3 yrs ago and they helped immensely. I had my first colonoscopy in May and there was one, tiny, benign polyp removed. This happened just a few days b4 Thanksgiving and has not let up since. None of the back-and-forth stuff like IBS. I just researched on Google (again) and the problem is, so much of these symptoms can be caused by stress. I really believe that I am not under any more stress than I was 6 mo's ago and that I have some condition. My stool sample came out normal (bacteria, ovum, parasites). One of the medications I read about is Lotronex, which prevents seratonin from acting on specific receptor sites within the gut known as 5-HT3 receptors. Does that interfere with-psychiatric medications that deal with-seratonin?