While discussing what to add to my son's medications yesterday, our psychiatrist said she had just read a preview of several clinical trials for EO BiPolar (BP) that will be coming out over the next several months/year. The review was sent to child psychiatrists (at least that's what she is) now because the findings were considered so important that getting the info into the hands of practicing psychiatrists could not wait for final publication. All the studies had passed peer review and it was just a matter of getting through the lengthy publication process. According to her, the clinical trial data found that AAP's are the most likely to provide good mood control while MS's are not as helpful in this group of patients. The results grouped three AAP's at the top and the others in the trial were not nearly as effective. According to our psychiatrist, the studies found Risperdal, Seroquel and Zyprexa to be all about equally effective trailed by Abilify and then at the bottom Geodon. I didn't think to ask which MS's were used in the trials but I assume Lamictal was one of them since we were talking in the context of my difficult child 2 being on Lamictal and Abilify. Thought some of you might be interested in this info. The draw back to the AAP's from our perspective is the metabolic effects. We have seen a big weight increase along with blood sugar increases to the point we may have to start him on Formalin a drug to treat pre-diabetes.