I am 47 years old, and I have been suffering the sweats and sleep disturbances for years. Mood swings and irritability have been the norm. My BS o'meter is just plain set to ultra-sensitive. My sex drive is non-existent. I have a genetic blood clotting disorder called Factor V Leiden. I had a pulmonary embolism in 1992. A lousy way to give up smoking, I might add. I have done tons of research on Hormone Replacement Therapy (HRT) and Factor V. Ten years ago, they would have told you to get onto blood thinners for the rest of your life no matter what else you did for your health. Now, the general consensus is that if you haven't had a clot in 10 years and you've only had one, your likelihood of having another is slim, and there is no reason for blood thinner treatment. Recent studies show that if you have Factor V, and you use transdermal HRT, your incidence of a clot only goes up to 4% from 2% if you don't have Factor V. I can not get my doctor to listen to me that I have been going through this for 5 years, my periods show no sign of slowing down, and I can't stand my hair trigger temper. It's likely I have another 5 years to go. He upped my Wellbutrin, that didn't help. He will under no circumstances allow HRT because of the Factor V. I've sent him copies of studies. No go. He decides that maybe it's more PMS that is increasing to PMDD. So, why not try eliminating my periods with Depo Provera? If I thought my irritability was bad before, I think that it's a miracle I haven't murdered someone in the past 8 weeks. Not to mention that I'm spotting half the time now. Sex drive remains the same. I have so little patience for husband and his shenanigans, we fight constantly. Last night he came up with this gem. "I was thinking about it today, and I realized that I don't do anything to make you happy." DUH! The first and last time he bought me anything was 2005. After I yelled at him that he has never bought me anything in the 19 years we had been married at the time. It was a two pound box of cheap chocolates. I don't eat sweets much, and if I do, it has to be something I like. I don't like cheap chocolates, and it's not like I have never mentioned that before. I was nice, though. I ate one then and there, then every day I'd take one or two and toss it down the disposal until they were gone. So, anyhoo I feel more miserable than ever. And husband has had more opportunity than ever to do stupid little things that peeve me that would be ok once in a while but I can't handle it day in and day out anymore. He says "I know you think I do these things to disrespect you but..." OK, dear, in the same situation with anyone you work with do you do what you do to me? "No". Why not? "They'd probably fire me." I look up side effects of Depo Provera. Irritability. UGH! I mean I know everyone has their ups and downs, but why try to cure woman of irritability with a grumpy shot? Another side effect can be musculoskeletal pain. I'm in chronic pain from my muscular dystrophy. WTH? So, on Monday I have an appointment with an OB/GYN who specializes in HRT and has connections with hematologists. If they will treat my peremenopause with appropriate medications, more changes in my diet, and I am still super-witch, I'll bite the bullet and check myself into a mental hospital if that is what it takes. But I am so sick and tired of doctors that tell me that every physical ailment I have is cause by depression, and no matter what medical study I can show them that links my symptoms to conditions I have they find it easier call me a crazy liar! No wonder I seem irritable! At the same time, I'm worried that I will run into the same barriers as I have before. Like we were saying in another thread, just because a doctor is supposed to be a specialist doesn't mean he doesn't have his head in his hoo-haw. Wish me luck!