difficult child 2 started Seroquel XR 300mg just as we started our trip last month, and since I was with him pretty much 24/7, I could really see how it was working for him. It seems that after about 16 hours it wears off. I'm wondering: What do other people do about covering the rest of the day until it's time for the evening dose? (Haven't checked in with the psychiatrist since we've been back, but will be doing that on Monday -- and it's good for me to get this down here to clarify things in my own head.) I see that it makes hiim REALLY sleepy and REALLY hungry. He is not as agitated and seems pretty well focused when he gets up in the morning (although he's tired), and he's fairly cooperative. But by lunchtime, he's increasingly restless, bored, hyperactive, emotionally reactive, easily frustrated and prone to loud outbursts and tantrums (not very long, though) which can include hitting (usually sibs) or throwing things. He also starts bugging people A LOT. Clearly, more tweaking and possibly an additional medication needs to be considered. He's still taking 500mg Depakote at night, too. I tried giving him 300mg of regular Seroquel during the day when we were on our trip, and it seemed to help get him through the afternoon and early evening, but he is just so sedated I don't see how this will be helpful in September. The food issue has to be addressed too. I could see the fat accumulating on his torso during the trip and he quickly found that the shorts I packed for him were too tight. I haven't weighed him, but I'll bet he's gained at least 10 pounds in the last month. Thanks in advance for any feedback or experience you can share!