yesterday at our appointment at UCLA. One of the researchers said she'd remembered reading something about Sydenham's Chorea and bipolar, found the book and copied the passage for me. There is evidence that some people who develop Sydenham's Chorea after a strep episode, and who are already predisposed to bipolar, are often catapaulted into bipolar disorder much sooner and possibly to a greater degree than if they'd never had the Sydenham's. It would explain why difficult child 2's bipolar symptoms became much more pronounced around the same time he was dealing with the aftermath and diagnosis of Sydenham's. It seems to fall under the whole PANDAS umbrella of psychiatric/neurologically based disorders stemming from a hostile autoimmune response to certain strep bacteria. It doesn't change things for us, but it's comforting in a way to understand why things happen.