Hello, This is my first post. My 10 year old daughter was diagnosed with Aspergers a few years ago. She is now also diagnosed with ADHD but possibly a mood disorder. Her reactions to medications point to possible mood disorder, not necessarily Bipolar, but maybe. She has ALWAYS been inflexible and defiant. She is extremely bright but over the last couple of years has more school work refusal issues. Also, over the past year or so she gets mad at us when we ask her to do anything that will cause the slightest discomfort.....take a shower, pick up a mess, stop watching TV, stop playing a video game etc. She will tell us to shut up or she tells us she hates us. When things are going well (she is having fun) then she seems fine. She seems sort of Aspie-like, but does not have too much awkwardness. She presents sort of in between Aspie and neurotypical. But when there is a problem (stress) and she is inflexible and defiant, she looks more Aspie. The issue now is that she is so moody, it looks like more than Asperger's is going on here. She can't seem to deal with the slightest demand, she is mean to us, she says hurtful things all the time, she doesn't seem very sorry about any of it either, which is very concerning. Things will be good and she will be happy but the minute something doesn't go her way a switch flips and she is hateful. She doesn't have moods that last very long. She goes back and forth several times a day. She is impulsive so she may hit or kick but I would't say she is "violent", she hasn't actually hurt anyone. So there is some physical aggression and a lot of verbal aggression. Like I said sometimes she is fine and fully functional. Does this sound familiar to anyone? We do see lots of docs who are all trying to figure her out. She has a very stable home and no one in the household/immediate family has any mental illnesses, though Bipolar does run in the family, as does depression. Thanks for listening, please feel free to ask questions!