Hi, Can anyone tell me if there is any difference between the different SSRI's like Zoloft, Prozac, Lexapro, etc? Are any of them better at treating Obsessive Compulsive Disorder (OCD) type symptoms? My son doesn't have a formal diagnosis but had been on Zoloft for about 3 years and it really helped him - no more crying and frustration over every little thing - much happier and helped with his Obsessive Compulsive Disorder (OCD) type behaviors. Perhaps he was a little more hyper but not enough to get in the way of his performance at school (gets very high grades)....it occurred mostly in the evening if he was bored. Just this year when he hit the puberty age (12) the Zoloft lost it's effect. He would become angry and rage about things, sometimes so extreme he couldn't stop himself. Afterwards he would feel awful and say it was like he was another person he had no control of. His psychiatrist started talking about mood disorder and weaned him off the Zoloft and started Lamictal, but when he hit 50mg he got really bad headaches and began displaying very manic-like symptoms that we had never seen in him before (different than the rages.) So we are weaning him off of it. So, now I'm wondering since the Zoloft had worked so well in the past would a different SSRI perhaps work for him. The psychiatrist has also suggested trying Risperdal or Abilify with an SSRI. He said the AP's would help with the rages. Do they also help with hyperactivity? (He is not ADHD - have tried stimulants - very unsuccessful). I have read a lot about Risperdal and Abilify and realize there are many SE's - especially weight gain. Any info or personal experiences would be much appreciated. If we could find another SSRI that works as well as the Zoloft originally did (without the rages), and an AP that would address the hyper symptoms that would be a good option. Also - he does have vocal tics occasionally - psychiatrist claims AP's can help with these (but I know they can also cause SE's that look like tics like TD) so that concerns me as well. Thanks for anything you can share - it's very stressful as you all know!