Hi Everyone. It's very hard to know where to begin with this post because so much has happened. Life has been very difficult. Our decision to wean difficult child of all medications was a very bad one. She has been cycling between hostility, which sometimes results in violence/destruction, and sadness and talk of self harm and suicide. We have been trying so hard to access local services, but here in Canada, the waiting lists are long and the process is slow. We have called the police twice, the local crisis line 3 or 4 times and have been to emerg twice because of her instability. Our last visit to the hospital was July 1. We got through 3 layers of staff and eventually ended up with a child psychiatrist but our situation did not meet criteria for admission. I wish I had asked what the criteria was, but unfortunately I completely fell apart with disappointment and fear about taking her home and I was unable to speak....I can get very messy sometimes, which really bugs me! So finally today I get a call from a nurse practitioner, that was referred to us, through the crisis line. She is said to have expertise in prescribing medications to adolescents with mental health issues. So following a 10 minutes conversation, she says she recommends we trial Zoloft and Seroquel and that she will drop off a prescription on her way to work in the morning. I find it very ironic that weeks of effort, trying to access some help, results in a quick phone call and the offer of a house call! It seemed so easy. Why did it have to take so long? Anyway, we're back on the spinning wheel. I'm afraid to be hopeful, because we've been here so many times, but the last couple of months tell me that we must keep trying until we find the right medication, because no medication was completely unbearable. I've read some posts here and other places that the Zoloft/Seroquel combination is effective for some and of course, a disaster for others.