How frustrating is this?! difficult child started on Zoloft not long ago. He caught a cold & was coughing a lot. psychiatrist said OTC remedies are OK, but gave us a couple of ingredients to avoid. I carefully avoided those & found some tablets with-dextromethorphan as the active ingredient. Checked the label -- it said to avoid interaction with MAOIs. OK, no problem. Checked with the pharmacist to be sure -- no problem. Checked the Zoloft patient information -- no problem. He took a couple of the tablets, and seemed a little more irritable than he has been lately. So I went to the internet, and a couple of usually reliable websites said to avoid taking dextromethorphan with MAOIs and SSRIs. I went into a tailspin, and called the pharmacy. A very nice pharmacist spent 20 minutes on the phone with me while she checked her (presumably more reliable) pharmacology websites & books. She found no drug interaction warnings for SSRIs & detrometorphan. Her guess was that the consumer websites incorrectly included both categories of antidepressants in the warning. I felt better, but decided to go back to plain old Ricola cough drops anyway. The moral of the story, I guess, is don't trust everything you read on the internet. Except this site, of course. Anyone else have issues combining OTC & Rx medications?