difficult child has been on it almost two months and has worked up from 50 mg per evening to 150mg. We have not seen much help with it. In fact, I wonder if things are worse. She has had lots of outbursts - especially in the last week. On Friday last week and almost everyday since, she has broken down in to tears and screaming fits. When we try to talk to her, she gets worse. If we try to console her she pushes us away. I will talk to her therapist tomorrow at her appointment - but we have over a week until we see the ARNP about the medication check. I called last week and told about the increased melt downs and they said to continue the rx. Do you have to wean off of Seroquel? I know she is still on a low dose, but I feel like we are treating her like a guinea pig. We saw the neuropsychologist yesterday, but since she didn't see difficult child she didn't have suggestions yet. She will be ordering tests... but it could take weeks to get insurance approval. I think I would rather deal with her on no medications... than what we are doing now. Possible dxs are: Anxiety,ADD, ODD, Dysthymic Disorder, Borderline Personality Disorder, Reactive Attachment Disorder (RAD), BiPolar (with hereditary factor); I knew about the anxiety, ADD and possible bipolar... but the other terms came up in the records I got copies of for the consult. Not as true diagnosis... but possible, or rule out diagnosis. husband and I are sitting here, unable to sleep after witnessing a horrendous meltdown, crying, screaming and her telling us we hate her. Not sure what to do anymore. KSM ps - from previous posts you may remember that Prozac made her feel "hyper" and she had animal type rages on Stratera. Those rages were different than these - in that she was angry - but now she is crying.