Well, we made the switch from Zoloft to Wellbutrin 3 days ago. I am not sure I am liking what I am seeing. She is just so very negative right now. Just really moody. She was really up and happy on the low dose of the Zoloft, but she wanted to try to switch because of the tiredness. I am scared with what I am seeing. I figured that switching from one to the other without missing doses we wouldn't experience this. She just seems angry and negative. I am sitting here freaking out over it of course because it is right before Christmas, and I want her to be happy and have a nice time. So, do I need to just give the Wellbutrin more time to "settle in" or do I call the psychiatrist and just go back to the low dose Zoloft. I am beating myself up right now, because I just should have waited until after Christmas to try and make the switch. Dummy me thought this would be easy. Why would that happen. Nothing around here lately seems to be easy. Ever.