I had a brain MRI yesterday to rule out MS, which it did to a 90 - 95% degree. However, it showed "subtle nonspecific white matter changes", which can mean a lot of things (it would normally be seen in someone in their 80's as a normal occurrence, means more when it's found in a younger person). I have headaches almost daily. They often get pretty intense. I haven't had any vicodin for a while because I haven't been having diffuse body pain that warrants it - so I haven't asked for it - and that is what I used to take for them. Now, I've been taking 600mg of ibuprofen, then 2 hours later 1,000mg of Tyelnol, followed by 600mg of ibuprofen in another 2 hours to try to knock it back to bearable. It doesn't get rid of the headache, but brings it down to a dull roar. So, my physiatrist is calling it chronic migraines (one of the possible differential diagnoses for the white matter changes) and put me on celebrex. He said celebrex is safer for my heart than ibuprofen. But, I've never heard it used this way. Anyone else take celebrex for migraines? I have to say, it has helped today, but it could be that it just wasn't going to be a bad one today. I'm to take it everyday, starting at once a day then increasing to twice a day. But, I'm now on two medications, the other being mestinon, that tear up my gut. If you take celebrex, is that something your body adjusts to?