I know that for seizure control, husband's neuro absolutely wants him on the brand because it's a much smaller window of therapeutic benefit, vs. a broad range medication like an antibiotic. I can imagine that some people could be more sensitive to changes in formulation when switching from brand to generic. It's always good to keep an eye on things when you first start a new medication, even if it's the "same" but generic version of what you usually take.
difficult child 1 takes an immunomodulator and his GI insists that he take brand because generics have shown to not be metabolized as well and therefore there is reduced clinical benefit. Unfortunately, our insurance disagrees and so we are charged nearly full retail for the brand -- which is why I ended up going to Canada for refills now!
JJJ, I had not heard about that effect! Is it permanent or reversible?