Over the past 3 years, difficult child 2 has tried Lexapro (caused headaches, feeling that something wasn't right), Prozac (couldn't sleep), Zoloft (suppressed her appetite, causing her to lose weight), Luvox (muscle twitches, impulsivity), and Paxil (2 days, raging). Some of her "side effects" like the muscle twitches, headaches, and feeling that something wasn't right could have ben her Lyme disease diagnosis'ed later. Her psychiatrist wants to try Zoloft again at a lower dose to help with her Obsessive Compulsive Disorder (OCD). I don't have much hope for this since she already tried it and had to be taken off. Has anyone tried a medication after a few years and had success? Or any other medications for Obsessive Compulsive Disorder (OCD) that are not SSRI's? She has tried Anafranil with bad side effects, Buspar, Elavil, and Topomax.