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Depakote and hyperammonemia
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<blockquote data-quote="KateM" data-source="post: 143541" data-attributes="member: 1973"><p>Sue, as I posted earlier, we've had experience with this. My son was on Depakote from 3rd to 10th grade without having an ammonia level done. Then, we switched docs (from neuro to psychiatrist). New doctor orders routine ammonia level -- it's elevated;son comes off Depakote.</p><p></p><p>For the next 3 years, we tried different medications with varying effectiveness and side effects, but nothing helped son with mood stability and handling frutration as well as Depakote. Some medications tried: trileptal ( increased ADD symptoms and caused concentration/memory problems),lithium ( worked well with Lamictal, but not on own), Lamictal (sleep problems), as well as AP serquol and ,later, resperidal (weight gain and constantly hungry).</p><p></p><p>I was researching any possible way son could take Depakote again and found some medication abstracts discussing how Depakote can cause an L-carnitine (amino acid )deficiency and this in turn causes the HA. Although L-carntine supplements are sold over the counter, a prescription strentgh is needed. The medication is called Carnitor.Here is some info from the presribing info -Additional Information</p><p>Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, levocarnitine is used in certain patients with the following medical condition:</p><p></p><p>Carnitine deficiency that results from treatment with valproic acid </p><p></p><p>My son has been back on Depakote since August (with the Carnitor) with great results! His ammonia level has been followed every 2 months. After being fine for 4 months, it suddenly shot up to 330 -- but psychiatrist said it must be a lab error. Son was retested and level was 80. His last level, 2 weeks ago, was 60.</p><p></p><p>So, if you feel Depakote is the best medication for your son, talk to the doctor about Carnitor supplementation.</p></blockquote><p></p>
[QUOTE="KateM, post: 143541, member: 1973"] Sue, as I posted earlier, we've had experience with this. My son was on Depakote from 3rd to 10th grade without having an ammonia level done. Then, we switched docs (from neuro to psychiatrist). New doctor orders routine ammonia level -- it's elevated;son comes off Depakote. For the next 3 years, we tried different medications with varying effectiveness and side effects, but nothing helped son with mood stability and handling frutration as well as Depakote. Some medications tried: trileptal ( increased ADD symptoms and caused concentration/memory problems),lithium ( worked well with Lamictal, but not on own), Lamictal (sleep problems), as well as AP serquol and ,later, resperidal (weight gain and constantly hungry). I was researching any possible way son could take Depakote again and found some medication abstracts discussing how Depakote can cause an L-carnitine (amino acid )deficiency and this in turn causes the HA. Although L-carntine supplements are sold over the counter, a prescription strentgh is needed. The medication is called Carnitor.Here is some info from the presribing info -Additional Information Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, levocarnitine is used in certain patients with the following medical condition: Carnitine deficiency that results from treatment with valproic acid My son has been back on Depakote since August (with the Carnitor) with great results! His ammonia level has been followed every 2 months. After being fine for 4 months, it suddenly shot up to 330 -- but psychiatrist said it must be a lab error. Son was retested and level was 80. His last level, 2 weeks ago, was 60. So, if you feel Depakote is the best medication for your son, talk to the doctor about Carnitor supplementation. [/QUOTE]
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