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<blockquote data-quote="Marguerite" data-source="post: 412784" data-attributes="member: 1991"><p>With chimeraism, from what I recall, entire organ systems are more likely to develop rather than an organ being made of multiple different tissue types. You need to think how an individual develops embryologically. So the brain, for example, is one organ and would have one genotype, not multiple genotypes. It would be most likely that the spinal chord and majority of the nervous system would be the same genotype. Eyes - likely to be similar to the brain, but it would be possible for one whole eye to be a different genotype to the other. I'm a bit rusty on my embryology, but you should see some sort of pattern(ectoderm, mesoderm, endoderm), which helps an embryologist go back and play detective, working out why and how the chimera happened. Mostly it's s source of intellectual curiosity. It wouldn't be impossible for one organ to have multiple genotypes, but it would be incredibly unlikely - chimeras are already rare, a chimera with multiple genotypes in one organ would be a fraction of 1% within the spectrum of chimeras.</p><p></p><p>That is just from memory, I haven't had tim to do any digging. My knowledge is also about 35 years old. But even though it seems haphazard, there is always a logic to it that makes sense in terms of the individual concerned. A bit like difficult child behaviour, really - it may seem chaotic to us, but there is always a reason that makes sense to the individual.</p><p></p><p>Marg</p></blockquote><p></p>
[QUOTE="Marguerite, post: 412784, member: 1991"] With chimeraism, from what I recall, entire organ systems are more likely to develop rather than an organ being made of multiple different tissue types. You need to think how an individual develops embryologically. So the brain, for example, is one organ and would have one genotype, not multiple genotypes. It would be most likely that the spinal chord and majority of the nervous system would be the same genotype. Eyes - likely to be similar to the brain, but it would be possible for one whole eye to be a different genotype to the other. I'm a bit rusty on my embryology, but you should see some sort of pattern(ectoderm, mesoderm, endoderm), which helps an embryologist go back and play detective, working out why and how the chimera happened. Mostly it's s source of intellectual curiosity. It wouldn't be impossible for one organ to have multiple genotypes, but it would be incredibly unlikely - chimeras are already rare, a chimera with multiple genotypes in one organ would be a fraction of 1% within the spectrum of chimeras. That is just from memory, I haven't had tim to do any digging. My knowledge is also about 35 years old. But even though it seems haphazard, there is always a logic to it that makes sense in terms of the individual concerned. A bit like difficult child behaviour, really - it may seem chaotic to us, but there is always a reason that makes sense to the individual. Marg [/QUOTE]
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