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IEA Hearing for difficult child at Hospital This Morning
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<blockquote data-quote="buddy" data-source="post: 496334" data-attributes="member: 12886"><p>I have no idea how Carbamazepine is metabolized... but I have shared before so those who have heard it go ahead and plug your.... eyes?</p><p></p><p>This may be totally off base but it caught us off guard so every time I hear this I share it just in case ... I am told it is not that rare and that soon enough people ar actually going to be better at dosing patients by considering this more routinely. Maybe that is a pipe dream??? But I was told that so doesn't mean it is right or anything... but the problem is for real. Mostly can make medicating tricky...but it also can be life threatening if large concentrations of medications accumulate without realizing this issue.</p><p></p><p>Q is a "poor metabolizer" for some medications based on a geneitic deficiency of certain enzymes needed to process some medications. (there are several and it all depends on which ones you have or dont have". Whether a rapid metabolizer or a poor metabolizer, in the end you can have too much medication in your system. People have died of overdoses from normally prescribed amounts. I am told depending on race... in general 6% of the population has some form of this. </p><p></p><p>So, for Q.... Prozac is on the list.... Since it does not exit the body at a normal rate, it can build over time. and eventually too much is in their bodies. I read story just a month ago about a boy who died after three days on Prozac with the same deficiency as Q has. (luckily when Q was on it our doctor suspected a problem and had only given him a small amount anyway.... and we reduced it wehn he went off in small increments too) Someone who rapidly metabolizes can break it all down too fast and then the blood amount is too high too. Or because it is broken down too fast it may result in too little in the system and then they need higher dosing to get the optimal amount. There are all kinds of inbetweens to that too. (not just is it there or is it not, and how much ... but the medication may not be broken down or transformed properly into the usable form so it is can be the body in a structure that is either harmful or not helpful at all etc....)</p><p></p><p>Of course there are testing errors that can explain things like this as well but it is always worth asking. Again, I have no idea if this is a drug that would be affected by this liver enzyme issue or not. It is easy to find out which enzymes are needed to metabolize it and then to check though. But it can be tested for. You can measure the enzymes... which does not mean you have the genetic form (for example some drugs actually can cause this issue)... and you can get the genetic tests done which I think many insurances will fight against unless there is compelling info that there could be a problem.</p><p></p><p>This article discusses one important one but in the context of a more reader friendly total explanation.</p><p></p><p><a href="http://www.anaesthetist.com/physiol/basics/metabol/cyp/Findex.htm#cyp.htm" target="_blank">Cytochrome P450 --- Just the basics!</a></p><p></p><p>There is a chart as you scroll down this article, you can click on your drug of interest and see what enzymes are involved and what happens given certain problems with an enzyme....</p><p></p><p></p><p>Technically boring warning: (not about the drug discussed here but same issue for any that are metabolized in the liver)</p><p></p><p><strong><span style="font-size: 18px">Clinical Pharmacology of SSRI's</span></strong></p><p><strong><span style="font-size: 18px"></span><span style="font-family: 'Times New Roman'"><span style="font-size: 15px">7 - Why Are CYP Enzymes Important When Considering SSRIs?</span></span></strong></p><p></p><p><a href="http://www.preskorn.com/books/ssri_s7.html" target="_blank">Clinical Pharmacology of SSRI's: Why Are CYP Enzymes Important When Considering SSRIs?</a></p><p></p><p></p><p></p><p></p><p>Just a thought....</p></blockquote><p></p>
[QUOTE="buddy, post: 496334, member: 12886"] I have no idea how Carbamazepine is metabolized... but I have shared before so those who have heard it go ahead and plug your.... eyes? This may be totally off base but it caught us off guard so every time I hear this I share it just in case ... I am told it is not that rare and that soon enough people ar actually going to be better at dosing patients by considering this more routinely. Maybe that is a pipe dream??? But I was told that so doesn't mean it is right or anything... but the problem is for real. Mostly can make medicating tricky...but it also can be life threatening if large concentrations of medications accumulate without realizing this issue. Q is a "poor metabolizer" for some medications based on a geneitic deficiency of certain enzymes needed to process some medications. (there are several and it all depends on which ones you have or dont have". Whether a rapid metabolizer or a poor metabolizer, in the end you can have too much medication in your system. People have died of overdoses from normally prescribed amounts. I am told depending on race... in general 6% of the population has some form of this. So, for Q.... Prozac is on the list.... Since it does not exit the body at a normal rate, it can build over time. and eventually too much is in their bodies. I read story just a month ago about a boy who died after three days on Prozac with the same deficiency as Q has. (luckily when Q was on it our doctor suspected a problem and had only given him a small amount anyway.... and we reduced it wehn he went off in small increments too) Someone who rapidly metabolizes can break it all down too fast and then the blood amount is too high too. Or because it is broken down too fast it may result in too little in the system and then they need higher dosing to get the optimal amount. There are all kinds of inbetweens to that too. (not just is it there or is it not, and how much ... but the medication may not be broken down or transformed properly into the usable form so it is can be the body in a structure that is either harmful or not helpful at all etc....) Of course there are testing errors that can explain things like this as well but it is always worth asking. Again, I have no idea if this is a drug that would be affected by this liver enzyme issue or not. It is easy to find out which enzymes are needed to metabolize it and then to check though. But it can be tested for. You can measure the enzymes... which does not mean you have the genetic form (for example some drugs actually can cause this issue)... and you can get the genetic tests done which I think many insurances will fight against unless there is compelling info that there could be a problem. This article discusses one important one but in the context of a more reader friendly total explanation. [URL="http://www.anaesthetist.com/physiol/basics/metabol/cyp/Findex.htm#cyp.htm"]Cytochrome P450 --- Just the basics![/URL] There is a chart as you scroll down this article, you can click on your drug of interest and see what enzymes are involved and what happens given certain problems with an enzyme.... Technically boring warning: (not about the drug discussed here but same issue for any that are metabolized in the liver) [B][SIZE=5]Clinical Pharmacology of SSRI's [/SIZE][FONT=Times New Roman][SIZE=4]7 - Why Are CYP Enzymes Important When Considering SSRIs?[/SIZE][/FONT][/B] [URL="http://www.preskorn.com/books/ssri_s7.html"]Clinical Pharmacology of SSRI's: Why Are CYP Enzymes Important When Considering SSRIs?[/URL] Just a thought.... [/QUOTE]
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