I can't take Lithium due to kidney issues, but I did switch from regular Depakote (valproic acid) to Depakote ER.
I LOVE the ER stuff. My blood levels used to be all over the map and I could really tell when it was wearing off, plus it upset my stomach.
Now, with the ER, my blood levels stay on an even keel, my stomach is much happier, AND I get better symptom control.
The one downside to the ER dosing is that I'm highly medication resistant and take a very high dose of Depakote. The pills are HUGE.