I would think so. Mood stabilizers don't treat acute phases, they treat the chronic condition. They reduce the amount of cycling over the long run. However, they can have an effect on the acute phase, as can so many other things. Lamictal is know to interfer with sleep for about three hours after being taken so it shouldn't be given to someone, especially before bedtime, who isn't sleeping. Conversely, one of the mood stabliziers which has the immediate effect of making someone sleepy -- Tegretol -- probably shouldn't be taken by someone, especially in the morning, who is already lethargic.