Personally I wouldn't do it. I would leave everything to all of them split equally.
This issue has caused so much heartache, distress and family rifts in our family. It's not just your relationship with your son, there's also the relationships between siblings who are left to deal with the fallout after your death and continued relationships between siblings and their children.
You don't know what might happen after your death and, personally, I think it's wrong to do this.