I was diagnosis'd with pernicious anemia back in February. I've had weekly B12 injections since that day. I rec'd a call from my doctor yesterday - not only has my B12 level not improved, it's gone down. My doctor is frustrated, I'm frustrated. My doctor is searching for further answers. In the meantime, I'm to start twice weekly injections here at home. I'm so tired of being tired; of the crushing fatigue that causes me to get done only what needs to be done versus what I'd like to accomplish. Has anyone ever dealt with this type of anemia that is so resistant to treatment?