Advances in depression and Obsessive Compulsive Disorder (OCD)



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New findings reported from University of Milan, Department of Psychiatry describe advances in depression

Researchers detail in 'Switching from serotonin reuptake inhibitors to duloxetine in patients with resistant obsessive compulsive disorder: a case series,' new data in depression. "Obsessive compulsive disorder (Obsessive Compulsive Disorder (OCD)) is a chronic disorder, currently recognized as one of the most common psychiatric disorder as well as one of the most disabling of all medical disorders. Obsessive Compulsive Disorder (OCD) is characterized by high rates of partial and/or absent response to standard, recommended treatments (serotonin reuptake inhibitors and psychotherapy)," scientists writing in the Journal of Psychopharmacology report (see also Depression).

"Recent investigation showed that Venlafaxine, a dual serotonin and norepinephrine reuptake inhibitor (SNRI), may be a valid alternative for some treatment-refractory patients. We present the cases of four Obsessive Compulsive Disorder (OCD) patients with comorbid mood or anxiety disorders, who were treated with serotonin reuptake inhibitors (SRIs) at adequate doses for at least 12 weeks, showing partial/no response. Patients were then switched to Duloxetine up to 120 mg/day and followed up for 12 weeks. Three out of four patients showed a Yale-Brown Obsessive Compulsive Scale(Y-BOCS) score reduction >or5%," wrote B. Dell'osso and colleagues, University of Milan, Department of Psychiatry.

The researchers concluded: "Duloxetine may be helpful in patients with treatment-resistant Obsessive Compulsive Disorder (OCD), although larger and controlled studies are warranted to confirm this preliminary observation."

Dell'osso and colleagues published their study in the Journal of Psychopharmacology (Switching from serotonin reuptake inhibitors to duloxetine in patients with resistant obsessive compulsive disorder: a case series. Journal of Psychopharmacology, 2008;22(2):210-3).

Additional information can be obtained by contacting B. Dell'osso, University of Milan, Dept. of Psychiatry, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy.

The publisher of the Journal of Psychopharmacology can be contacted at: Sage Publications Ltd., 1 Olivers Yard, 55 City Road, London EC1Y 1SP, England.

Keywords: Italy, Milan, Depression, Analgesic, Antidepressant, Anxiety Disorder, Drug, Duloxetine, Mental Health, Obsessive-Compulsive Disorder, Pharmaceuticals, Pharmacology, Psychiatric, Psychiatry, Psychology, Psychopharmacology, Psychotherapy, SSRI, Serotonin Reuptake Inhibitors, Therapy, Treatment, Venlafaxine.

This article was prepared by Mental Health Weekly Digest editors from staff and other reports. Copyright 2008, Mental Health Weekly Digest via

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Active Member
Interesting. When we were trying to treat my daughter's Obsessive Compulsive Disorder (OCD) with medicine, we had run out of options. The SSRI's seemed to help her but came with unacceptable side affects. The psychiatrist was going to start trying other medications but was out of the accepted therapies for Obsessive Compulsive Disorder (OCD). If we ever get to that point again, it is good to know there is a new option.