So Strawberry (the name I just chose for the little difficult child) just started her Metadate last Friday. I didn't really notice much of a change. She is on 10mg. She is also taking 3mg Melatonin at night, which is working very very nicely. Well this morning she had a hard time getting up, so we were late getting out the door. Consequently we missed giving her the Metadate. NOW I see the difference. She has been a MONSTER today. I pick her up from school. How was your day, I ask. "MOM, do you have to know EVERYTHING?" And that merely set the tone. I won't go into everything. I will tell you that I just came from a time out I gave myself in my room, where I was banging my own head against the wall in frustration. Point is, the change was not obvious when she began taking it, but WOW I noticed it on the day she missed it. Let's not do that again, shall we?