Highest association found during first trimester exposure for autism and third trimester exposure for developmental delays In a study of nearly 1,000 mother-child pairs, researchers from the Bloomberg School of Public health found that prenatal exposure to selective serotonin reuptake inhibitors (SSRIs), a frequently prescribed treatment for depression, anxiety and other disorders, was associated with autism spectrum disorder (Autism Spectrum Disorders (ASD)) and developmental delays (daughter) in boys. The study, published in the online edition of Pediatrics, analyzed data from large samples of Autism Spectrum Disorders (ASD) and daughter cases, and population-based controls, where a uniform protocol was implemented to confirm Autism Spectrum Disorders (ASD) and daughter diagnoses by trained clinicians using validated standardized instruments. The study included 966 mother-child pairs from the Childhood Autism Risks from Genetics and the Environment (CHARGE) Study, a population-based case-control study based at the University of California at Davis' MIND Institute. The researchers broke the data into three groups: Those diagnosed with autism spectrum disorder (Autism Spectrum Disorders (ASD)), those with developmental delays (daughter) and those with typical development (TD). The children ranged in ages two to five. A majority of the children were boys – 82.5% in the Autism Spectrum Disorders (ASD) group were boys, 65.6% in the daughter group were boys and 85.6% in the TD were boys. " While the study included girls, the substantially stronger effect in boys alone suggests possible gender difference in the effect of prenatal SSRI exposure. "We found prenatal SSRI exposure was nearly 3 times as likely in boys with Autism Spectrum Disorders (ASD) relative to typical development, with the greatest risk when exposure took place during the first trimester," said Li-Ching Lee, Ph.D., Sc.M., psychiatric epidemiologist in the Bloomberg School's Department of Epidemiology. "SSRI was also elevated among boys with daughter, with the strongest exposure effect in the third trimester." Serotonin is critical to early brain development; exposure during pregnancy to anything that influences serotonin levels can have potential effect on birth and developmental outcomes. The prevalence of ADS continues to rise. According to the Centers for Disease Control and Prevention, an estimated 1 in 68 children in the U.S. is identified with ADS, and it is almost five times more common among boys than girls. One may question whether the increased use of SSRI in recent years is a contributor to the dramatic rise of Autism Spectrum Disorders (ASD) prevalence. "This study provides further evidence that in some children, prenatal exposure to SSRIs may influence their risk for developing an autism spectrum disorder," said Irva Hertz-Picciotto, Ph.D., M.P.H., chief of the Division of Environmental and Occupational Health in the UC Davis Department of Public Health Sciences and a researcher at the UC Davis MIND Institute. "This research also highlights the challenge for women and their physicians to balance the risks versus the benefits of taking these medications, given that a mother's underlying mental-health conditions also may pose a risk, both to herself and her child." Regarding treatment, the authors note that maternal depression itself carries risks for the fetus, and the benefits of using SSRI during pregnancy should be considered carefully against the potential harm. The researchers also note that large sample studies are needed to investigate the effects in girls with Autism Spectrum Disorders (ASD). Limitations of the study acknowledged include the difficulty in isolating SSRI effects from those of their indications for use, lack of information on SSRI dosage precluded dose-response analyses, and the relatively small sample of daughter children resulted in imprecise estimates of association, which should be viewed with caution. Source: Johns Hopkins University Bloomberg School of Public Health Study Reference: The data analysis was completed by Rebecca Harrington, Ph.D., M.P.H, in conjunction with her doctoral dissertation at the Bloomberg School. Dr. Lee was one of her advisors. Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ConductDisorders or its staff.