I've tried SSRIs: Prozac, Zoloft, Paxil and tricyclics: amitryptilene, tofrinil, nortryptelene (all spelled wrong) and this is what I found. Sadly, I know about patient response to medications based on being in the hospital myself three times, at one time for ten weeks when insurance actually covered your stay. The tricyclics, in my opinion, work LESS well than the SSRIs for depression. I found the side effects horrible, including psychosis. The only one I could tolerate was nortryptylene, and that maybe helped me only 50%. I was still not functioning well. Then the SSRI's came out and I had hideous side effects to both Prozac and especially Zoloft. But, again while in the hospital, the patients seemed to do better on the SSRI's than when there were only tricyclics. Paxil works well for me. I have no idea why. It's been eleven great years. Effexor is an SNRI. Straterra is an SNRI. Wellbutrin is different--not sure what. My hub, who has no disorder and is usually calm, took it to stop smoking and it didn't help him stop (he since stopped on his own). It did make him so nervous that he tossed it in the trash. There are no medication guarantees and for kids none are really that great, in my opinion--I'd watch any child on any sort of antidepressant. There are also withdrawal effects. I had them from tricyclics as well as SSRIs and they aren't fun. The worst withdrawal I had was from tofrinal. I ended up back in the hospital because I started acting bizarre and suicidal. I deliberately crashed our car into the cement wall of the garage and I *knew* I wasn't "right" but couldn't help it. It took a while each time to get the drugs out of my system, and I've been tempted to try quitting, but each time I do, even after the darn drug wears off, I fall into a deep depression. Sometimes you have no choice.