DS12's depression keeps getting worse. We tried Zoloft and then Celexa after a Zoloft fail. With both the Zoloft and Celexa we saw huge improvements and then major backslides. We then ruled out SSRIs and tried Lamictal. As we were titrating up there was almost a switch overnight at 150 and I felt like I had my son back. Less than a week later he completely regressed. We titrated to 200 and the results were amazing. Fast forward three weeks and now we are back to where we started. I have a call into his P-doctor to see if we increase Lamictal or try something else? At one point he had mentioned Abilify as a future something to consider. I just received an email from school and he melted down and started hitting himself then when brought to the hall was banging his head on a locker as punishment to himself since he is "so stupid." I've caught him with a knife before and we are one step away from him engaging in cutting which he has expressed interest in before. I hate that he is going through this and I know there is no magic pill but any advice or experience you can share would be great. Thanks!