My difficult child has been doing exceptionally well after 2 hospital stays, and the addition of medications. We waited, and made no medication changes for quite some time after discharge. He has really been like a easy child, but everyone felt that he was not on a medication combination that made any sense. He can't even have his wisdom teeth out until medication changes are made, due to interactions with anesthesia according to psychiatrist. The magic combination was 150 mg Zoloft, 150 mg Wellbutrin, 50 mg Lamictal, and 5 mg zyprexa. He had tried Both Zoloft and Wellbutrin on their own and neither worked. The change for the best while he was hospitalized seemed to happen after the addition of the Lamictal. The psychiatrist wanted to get him off the Wellbutrin, so that is what we are doing. We switched from the extended resease 150 mg 1X/day to nonextended release 75 mg/2x a day for 2 weeks. Last Friday we went down to 75 mg once each day. After 2 weeks we are to discontinue it. Now difficult child says that he is not feeling "right", and is having difficulty with motivation, and getting certain assignments started at school. Over the weekend I had difficulty getting him motivated to do some activities that he previously was excited about doing. He can tell that something does not feel right, we can tell that things are getting somewhat worse, and the school is seeing it as well. I emailed the psychiatrist last night to let him know, and we have a therapist appointment tonight. The question I am asking myself is....are the difficulties due to the changes he is experiencing from coming off the Wellbutrin and will he start to feel better in time, does he really need the Wellbutrin, or does he need adjustments in the other medication dosages to compensate somehow. I realize that this is probably guesswork, and trial and error. Does anyone have any ideas, personal experience, or opinions?