We have pretty much run out of AD's to try - unless we want to try the tryciclics (sp). Nothing has helped much (Zoloft, Welbutrin, Celexa, Lexapro, etc), and Prozac made difficult child intensely depressed complete with suicidal ideation and, at one point, a note and a plan. We are currently doing a medication wash. The biggest thing we need to target is the anxiety. Off the Prozac, her depression is pretty benign as depression goes. Although, Prozac is the only medication that worked on her anxiety. Frustrating. On the Prozac her anxiety was under control, but her depression was severe and debilitating, and she was sleeping all of the time. Off the Prozac, her anxiety is sky high, her depression is all but gone (and I think it stems from the anxiety to begin with), and she's not sleeping much at all. I am hesitant to try the AP's because difficult child's cholesterol is already high (after taking Abilify for a short time) and she is at high risk of heart disease because of me. I'm not sure what route to go and want to have some ideas before going back to the doctor. TIA.