Well, the more I research this the more I am convinced!! Now All I have to do is get some Gluten free CEREAL!!!!!!!!!!! We have recognized that Gluten-related diseases involve the absorption of complete proteins such as gliadin or its peptide-fragments. Anti-protein antibodies circulating in the blood and immune-complexes, combining antibody with food protein, provoke the release of mediators which may cause multiple disturbances in all body systems and tissue damage. These circulating problems influence brain function in a variety of undesirable ways. A family history of psychiatric problems is more common in patients with celiac disease. Celiac disease is genetically determined involving two or more concurrent genes. The genes involved are part of the immune-recognition complex, which determine the "Self" identity markers, protecting one's own cells from attack by the immune system. Celiac patients have an increased frequency of the serum histocomptability antigens (self-markers) of the HLA-B8 and HLA-Dw3 types. This genetic marker may indicate a predisposition for bowel absorption abnormalities or immunologic propensities that result, not only in celiac disease itself, but other contingent abnormalities as well. Schizophrenia has been associated with gluten intolerance. The diagnosis, schizophrenia, describes a variety of differing individuals who belong to complex group of brain-disordered people often with a chronic or relapsing disease that leads to dementia. The schizophrenic process distorts sensing, feeling, remembering, deciding, and acting. It is unlikely that schizophrenia is a single disease with a single cause. The milder, but similar brain dysfunctions observed with gluten allergy suggests that food allergy may play a role in schizophrenia, with gluten as a set of triggering antigens. Dr. F.C.Dohan consistently advocated a gluten-schizophrenia link. (Dohan FC Cereals and Schizophrenia: Data and hypothesis. 1966 Acta Psychiatr. Scand 42:125-42 and Dohan FC More on Celiac Disease as a model for schizophrenia. 1983 Biol. Psychiatry 18:561-4) Dohan stated: " Many diseases are caused by genetically-deficient utilization of specific food substances. Perhaps the best studied example is phenyketonuria... far more common disorders, for example, atherosclerosis, and coronary heart disease, are strongly suspected of being due to genetically defective utilization of certain food constituents. " Similarly, considerable evidence indicates that the major cause of schizophrenia is the inborn inability to process certain digestion products of some food proteins, especially cereal grain glutens..." Among Dr. Dohan's interesting an relevant recommendations is the idea of a "Gluten tolerance test". Such a test has not yet been developed, but is the sort of evaluation method that NP advocates in general. A gluten tolerance test could be initiated with routine evaluations before and after ingestion of grain foods. More sophisticated versions would measure gluten proteins and derived peptides in the blood, and would track the path of these molecules into organs, especially the brain. Finally the impact of these molecules would be evaluated by monitoring the function of the target organ in real time. I have been eager to do real-time monitoring of brain activity, topologically-computed in gluten-sensitive patients. These patients report changes in their energy, mood, cognitive abilities and emotions which no researcher to date has documented objectively. The problem of adverse brain effects of molecules derived from food is a major under-recognized phenomenon of nutrition and molecular pathophysiology. Research in the next 10-20 years will, I am convinced, reveal a great deal about the extent, mechanisms, and importance of this consequence of eating problematic foods to our mental status. ------------------ Nancy ODD/BIPOLAR/ADD Girl 6 1/2 yrs Off All medications Fav. Funny quote-"Yesterday I was a dog. Today I'm a dog. Tomorrow I'll probably still be a dog. <Sigh!> There's so little hope for advancement." - Snoopy With Out GOD, my life would fall apart!!!!!