Has anyone seen their difficult child become more anxious, aggitated and aggression on Seroquel? psychiatrist raised Tigger's Seroquel from 25mg to 50mg when we told him that Tigger was very anxious at school. The anxiety kept increasing so he added Ativan the next month. I use medication trays to keep us oganized because between the kids we have so many different medications and vitamins. I had forgotten when filling the medication trays for this week that I didn't have enough Seroquel for all 7 days and when I picked up the refill, I forgot to go and add it to the days that still needed it. So, Tigger went 3 days without it. He has been calmer, happier and less anxious.