Benedryl and seizures


Active Member
Just got back from a trip to CHOP for Missy for a f/u for the seizures. I got to talking to her about Benedryl and how it makes Missy nuts for a few days. I never give it to her, unless she has an urgent need for it. The neuro told me that Benedryl lowers the threshold for seizures. So those of you whose children have a seizure disorder, stay away from Benedryl.

Stella Johnson

Active Member
I never made the association before now and I hadn't heard that before. It does explain alot about my difficult child though. She goes bananas after taking it.



Even for kids who don't have seizures, Benadryl can have a paradoxical effect of hyperactivity and agitation instead of sedation.


Yes, both Loth and Smallworld are right on.

When my difficult child was much younger, we gave this to him a few times. Each time, he would initially be drowsy and sometimes fell asleep. But then he would wake up and be wired! Although he doesn't have overt seizures, he has an abnormalEEG.

We've stayed away from Benedryl for years now because of this.