Just got back from a trip to CHOP for Missy for a f/u for the seizures. I got to talking to her about Benedryl and how it makes Missy nuts for a few days. I never give it to her, unless she has an urgent need for it. The neuro told me that Benedryl lowers the threshold for seizures. So those of you whose children have a seizure disorder, stay away from Benedryl.