Child's autism risk accelerates with mother's age over 30


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Older parents are more likely to have a child who develops an autism spectrum disorder (Autism Spectrum Disorders (ASD)) than are younger parents. A recent study from researchers from the Drexel University School of Public Health in Philadelphia and Karolinska Institute in Sweden provides more insight into how the risk associated with parental age varies between mothers' and fathers' ages, and found that the risk of having a child with both Autism Spectrum Disorders (ASD) and intellectual disability is larger for older parents.

In the study researchers report that fathers' and mothers advancing ages have different impacts on their child's risk. The rise in Autism Spectrum Disorders (ASD) risk with parental age was greater for older mothers as compared to older fathers.

"The open question at hand really is, what biological mechanisms underlie these age effects?" said Brian K. Lee, PhD, an assistant professor in the Drexel University School of Public Health and research fellow of the A.J. Drexel Autism Institute, and senior author of the study. The observed differences in risk based on mothers' and fathers' ages point to a need to continue investigating underlying mechanisms of Autism Spectrum Disorders (ASD) that may be influenced by a mother's age, Lee said, even though much recent discussion has focused on fathers' and even grandfathers' ages.

The risk of having a child with Autism Spectrum Disorders (ASD) had a more complicated relationship to age in women than in men – whose risk of fathering a child with Autism Spectrum Disorders (ASD) increased linearly with age across their lifespan. Among women giving birth before the age of 30, the risk of Autism Spectrum Disorders (ASD) in the child showed no association with age -- it was simply very low. But for babies born to mothers aged 30 and older, the chance of developing Autism Spectrum Disorders (ASD) rose rapidly with the mother's age.

Lee noted that the non-linear maternal age effect that is relatively stronger than the paternal age effect on Autism Spectrum Disorders (ASD) risk has been observed in previous studies, but has not received much attention.

Multiple mechanisms could be in play to account for the different patterns of risk, including environmental risk factors occurring in women after age 30. Factors such as complications in pregnancy could also underlie the effect of mothers' ages on a child's Autism Spectrum Disorders (ASD) risk but not a paternal age effect. The linear, steady increase in risk associated with fathers' ages is consistent with the hypothesis of increased genomic alterations over the father's lifespan that can increase risk of Autism Spectrum Disorders (ASD), Lee said.

In this study, Lee and colleagues analyzed a large population registry sample of 417,303 children born in Sweden between 1984 and 2003, adjusted for numerous possible factors that could vary with parental age and also influence risk, such as family income and each parent's psychiatric history. The study also used a particularly comprehensive case-finding approach, to identify more Autism Spectrum Disorders (ASD) cases than other studies might, based on all pathways to care in a socialized health system.

A goal was to study these parental age effects in more detail by looking at possible differing risks of Autism Spectrum Disorders (ASD) with and without intellectual disability – one of the most serious comorbid diagnoses with Autism Spectrum Disorders (ASD), with a significant impact on functional status in life. This was the first population-based study with an Autism Spectrum Disorders (ASD) sample large enough to study Autism Spectrum Disorders (ASD) risk in populations of children with and without intellectual disability.

"When considering risk factors, we can't necessarily lump all Autism Spectrum Disorders (ASD) cases together, even though they fall under a broad umbrella of autism," Lee said. "We need to keep an open mind in case intellectual disability might be a marker of a different underlying mechanism." The finding that Autism Spectrum Disorders (ASD) with intellectual disability had a stronger association with older parents, compared to Autism Spectrum Disorders (ASD) without intellectual disability, supports continued investigation of possible different mechanisms.

Lee noted that, although age effects are important indicators of risk at the population level that could eventually help researchers identify preventable causes of disability, they aren't very significant for a couple's family planning because the overall risk remains low. "The absolute risk of having a child with Autism Spectrum Disorders (ASD) is still approximately 1 in 100 in the overall sample, and less than 2 in 100 even for mothers up to age 45."

Drexel University

Study Reference:
Published in the February 2014 issue of the International Journal of Epidemiology

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