Desmopressin seizure alert

Discussion in 'General Parenting' started by TerryJ2, Dec 4, 2007.

  1. TerryJ2

    TerryJ2 Well-Known Member

    Just got this in my mailbox. My difficult child uses this orally to prevent bedwetting, if he spends the night at someone's house. Luckily, it's only used on occasion, and never as a nasal spray.

    FDA notified healthcare professionals and patients of the Agency's request that manufacturers update the prescribing information for desmopressin to include important new safety information about severe hyponatremia and seizures. Certain patients, including children treated with the intranasal formulation of the drug for primary nocturnal enuresis (PNE), are at risk for developing severe hyponatremia that can result in seizures and death. As such, desmopressin intranasal formulations are no longer indicated for the treatment of primary nocturnal enuresis and should not be used in hyponatremic patients or patients with a history of hyponatremia. PNE treatment with desmopressin tablets should be interrupted during acute illnesses that may lead to fluid and/or electrolyte imbalance. All desmopressin formulations should be used cautiously in patients at risk for water intoxication with hyponatremia.
  2. gcvmom

    gcvmom Here we go again!

    Thanks for passing that along. easy child/difficult child 3 takes that for secondary NE (she was dry for about two years, then suddenly started having issues again -- possibly stress related because of :censored2: our family is going through) although it has yet to work for her. She's not prone to hyponatremia, but that's a good flag to wave anyway.