Oh yes! I started out on Celexa, an SSRI, about seven years ago. It worked so-so for about a year, but just didn't help enough. Our psychiatrist switched me to desipramine (Norpramin), a much older tricyclic, and it's worked the best for me so far.
My initial diagnosis was depression, but it also has to do with the anxiety and stress I'm under because of the circumstances of my life (difficult children included). When a person is under constant stress, it can weaken you body's coping mechanisms. For some of us, once the stressful situation resolves, we get back to our "old" selves. For others (like myself) with a family history of depression and anxiety, we are predisposed to having stress push us over the edge and keep us there, even when the stressor is gone.
I've got no problem admitting that I need medication to function effectively in my life. Just as I would have no problem admitting that I needed glasses to see or insulin to digest my food or an inhaler to breathe freely. It's not a reflection of my character, it's just the way I am, and I'm grateful to have it as a support.